Custom Peptides
ABclonal Technology Phospho-IRAK4-Thr345/Ser346 Rabbit pAb
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Cayman Chemical RutaecarpIn 10mg
A quinazolinone alkaloid with diverse biological activities; inhibits COX-1 and COX-2 in BMMC cells (IC50s = 8.7 and 0.28 µM, respectively); selective for COX-2 in HEK293 cells (IC50s = >400 and 2.8 µM, for COX-1 and COX-2, respectively); slows cancer cell growth in vitro (GI50s = 8.41-31.6 µM); induces vasodilation (0.1-10 µM) in isolated rat aorta; decreases plasma levels of caffeine in rat through CYP1A2 and CYP2E1 metabolism induction at a dose of 80 mg/kg
Cayman Chemical TesaglItazar 10mg
A dual agonist of PPARα and γ (IC50s = 1 and 0.2 µM, respectively) that at 3 µM/kg/day for 3 weeks has been used to reduce insulin resistance in obese Zucker rats
Cayman Chemical Pralatrexate 10mg
A DHFR inhibitor (Ki = 13.4 pM) and antifolate; inhibits growth of acute lymphocytic leukemia cells (IC50 = 0.04 μM), MDA-468, SK-BR-3, and ZR-75-1 breast cancer cells (IC50s = 0.11, 0.28, and 0.26 μM, respectively), and SK-LC8 and SK-LC16 NSCLC cells (IC50s = 0.42 and 0.11 μM, respectively); increases median survival in vivo in an H9 T cell lymphoma mouse xenograft model
Cayman Chemical 6-ProstaglndIn I1 10mg
6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.{509,1926}
Cayman Chemical Sceletum trtuosum Mesem 10mg
An alkaloid with 5-HT reuptake inhibitory activity; selectively binds to the 5-HT transporter (SERT; IC50 = 4.3 UG/ml) over a variety of receptors (IC50s = 148->750 UG/ml); inhibits 5-HT reuptake in vitro (Ki = 1.4 nM); has analgesic effects in the hot plate test at 20 mg/kg without inducing preference in the CPP test
Cayman Chemical 15 S-Fluprostenol 10mg
An isomer of fluprostenol; a potential active metabolite to 15(S)-fluprostenol isopropyl ester
Cayman Chemical SW203668trIfluoROCTAte sa 10mg
An irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM); selectively cytotoxic to cancer cell lines that express CYP4F11 over those that don't (IC50s = 22-116 and >10,000 nM, respectively); reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and NOD-SCID mouse xenograft models at 20 and 6 mg/kg, respectively
Cayman Chemical PseudomonIc AcId 10mg
An antibiotic; bacteriostatic against S. aureus (MIC = 0.05 UG/ml); active against skin wound clinical isolates of MRSA (MICs = 1-4 UG/ml); inhibits MRSA and P. aeruginosa biofilm formation in vitro; inhibits bacterial cell wall isoleucyl-tRNA synthetase; topical administration reduces the number of wound CFUs in a mouse model of MRSA skin infection at 2% v/v
Cayman Chemical Loteprednol etabonate 10mg
A glucocorticoid receptor agonist with an affinity 4.3 times that of dexamethasone; minimizes scarring of rabbit cornea wounds
Cayman Chemical Daursoln 10mg
An alkaloid with diverse biological activities; enhances camptothecin-induced cytotoxicity in HeLa cells at 10 µM; inhibits camptothecin-induced autophagy in HeLa, A549, and HCT116 cells (IC50s = 74.75, 50.54, and 80.81 μM, respectively); inhibits ADP-induced aggregation of platelets in isolated rabbit whole blood (IC50 = 100 µM); prolongs APD and reduces EADs in papillary muscle preparations isolated from hypertrophied rabbit hearts at 15 µM
Cayman Chemical Ajmalcn 10mg
A terpenoid indole alkaloid; an α1-AR antagonist that reduces the phenylephrine-induced pressor response in pithed rats at 1-4 mg/kg; binds to α2A-, α2B-, α2C-, and α2D-ARs (Kis = 8.2, 14.5, 5, and 289 nM, respectively); improves hemodynamic and metabolic parameters following transient cerebral ischemia in dogs when used in combination with almitrine
Cayman Chemical SynthetIc NImbIn 10mg
A limonoid with diverse biological activities; inhibits the growth of D. oryzae by 64.8% at 1,000 ppm; has antifeedant activity against S. littoralis in a choice test at 0.02-2,000 μM; decreases melanin content to 20.9% of control in B16 murine melanoma cells at 25 μg/ml; inhibits TPA-induced activation of EBV-EA in Raji cells (IC50 = 499 mol ratio/32 pmol TPA)
Cayman Chemical CerdulatInIb 10mg
A dual inhibitor of Syk and JAK (IC50s = 32, 12, 6, 8, and 0.5 nM for Syk, JAK1, JAK2, JAK3, and TYK2, respectively); exhibits nanomolar inhibition of other kinases; inhibits JAK1/3-mediated STAT phosphorylation with IC50 values ranging from 0.16 to 1 μM; antitumor activity with IC50 values ranging from 0.05 to 2.1 μM against DLBCL tumor cell lines